Locked nucleic acid molecular beacons.
نویسندگان
چکیده
A novel LNA-MB (molecular beacon based on locked nucleic acid bases) has been designed and investigated. It exhibits very high melting temperature and is thermally stable, shows superior single base mismatch discrimination capability, and is stable against digestion by nuclease and has no binding with single-stranded DNA binding proteins. The LNA-MB will be widely useful in a variety of areas, especially for in vivo hybridization studies.
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 127 45 شماره
صفحات -
تاریخ انتشار 2005